tarlatamab is reported as the second-line standard after platinum in small-cell lung cancer with overall survival of 13.6 months versus 8.4 months for chemotherapy. Extended follow-up shows 30.3% of patients alive at 2 years and no new long-term safety signals.
Key points
OS 13.6 mo vs 8.4 mo (HR 0.62) in Dellphi-304 extended follow-up.
2-year OS 30.3% vs 14.9%; ORR 35.4% vs 20.4% versus chemotherapy.
Sources
Biohub $1.8 billion effort to build a virtual cell
Biohub announced a $1.8 billion program to generate data for a “virtual cell” model that predicts cellular behavior. The effort targets the fundamental data gap in cell measurements and plans a first dataset in about a year with useful models within five years.
Key points
$1.8 billion announced to fund data generation for a virtual cell.
Zero-shot protein design reduces hundreds of thousands of candidates to ~100, requiring 24 hours of computation and seven days of lab work.
Sources
Doximity Ask dosing errors study shows 2% wrong doses
Doximity Ask reports that testing 8,000+ physician dosing questions on 9 popular LLMs found over 2% of dosing claims were wrong, with almost half of those errors serious or potentially lethal. The service now checks every dose before showing it.
Key points
8,000+ physician dosing questions run through 9 popular LLMs.
Over 2% of dosing claims were wrong; almost half of those errors were serious or potentially lethal.
Sources
- Original post
- blog.doximity.com - Linked in the post
Biohub Imaging Residency adds 18 scientists
Biohub Imaging Residency adds 18 scientists from 10 institutions to work on cryo-electron tomography, advanced light microscopy and computational imaging. The program embeds these researchers in Biohub research teams.
Key points
Residents: 18 leading scientists
Institutions: 10 participating institutions
Sources
Overtraining may disrupt the brain's dopamine regulation
Overtraining may disrupt the brain's dopamine regulation, leaving levels elevated during rest. Mice that underwent chronic intensive training showed hippocampal dopamine remaining high for 48 hours after an exercise test during their rest phase. The same mice also had elevated tyrosine hydroxylase levels for the same period.
Key points
Dopamine in the hippocampus stayed elevated 48 hours after the performance test during the mice’s rest phase.
Tyrosine hydroxylase levels remained elevated for 48 hours in the chronic training group.
Sources
Paperclip Datasets launch live data collection tool
Paperclip Datasets is live, letting users describe a table and have agents gather data from papers, patents, trials and regulatory documents. Each value links to its source passage for verification.
Key points
Live service: agents collect data from papers, patents, trials and regulatory documents.
Source linking: every value includes a link to the originating passage.
Sources
- Original post
- paperclip.gxl.ai - Linked in the post
- gxl.ai - Linked in the post
RESONATE fourth clinical trial site activated at UTHealth Houston
RESONATE adds its fourth clinical trial site, now active at UTHealth Houston. The announcement thanks João de Quevedo and his team for support.
Key points
Fourth clinical trial site for RESONATE is active at UTHealth Houston.
João de Quevedo and his team provided enthusiastic support.
Sources
Butterfly Garden first commercially available SDK partner DeepEcho announced
Butterfly Garden announces DeepEcho as its first commercially available SDK partner, aiming to bring AI-supported ultrasound workflows to more care settings and markets worldwide. The post provides a link to learn more about DeepEcho.
Key points
First commercially available SDK partner: DeepEcho
Goal: bring AI-supported ultrasound workflows to more care settings and markets worldwide
Sources
- Original post
- training.deepecho.io - Linked in the post
