Orion-like capsule hypersonic reentry simulated in 10 min on a single H200 GPU. Solver built and verified in about 20 seconds, then optimized, run, visualized and analyzed.
Key points
Build time: around 20 seconds to build (and formally verify) the solver.
Run time: around 10 minutes to build, optimize, run, visualize, and analyze the simulation on a single H200.
Sources
BindClaw announces protein design pipeline with subnanomolar binders
BindClaw connects biological mechanisms to protein design and reports 15 of 18 designs binding calcium-loaded CaM, including subnanomolar binders verified by BLI and SPR. The project page and code release are forthcoming.
Key points
15 of 18 designs showed binding to calcium-loaded CaM.
Subnanomolar binders were supported by both BLI and SPR.
Sources
- Original post
- research.nvidia.com - Linked in the post
elranatamab MagnetisMM-32 trial topline results announced
elranatamab monotherapy was compared with investigator's choice of EloPd, PVd or Kd in the MagnetisMM-32 trial. The trial enrolled 523 patients with 1 to 4 prior lines of therapy.
Key points
Trial size: 523 patients
Comparison arms: investigator's choice of EloPd, PVd or Kd
Sources
Young-onset CRC atlas – largest single-cell atlas of colorectal cancer released
Young-onset CRC atlas published in Nature Medicine presents the largest single-cell atlas of colorectal cancer. It reports age-associated differences that may explain why colorectal cancer can be more aggressive in younger adults.
Key points
Atlas of young-onset CRC published in Nature Medicine.
Identified age-associated differences that may help research into aggressive colorectal cancer in younger adults.
Sources
Macaque brain cells timing 15 Hz switch visible vs suppressed
Macaque brain cells switched responses between visible and suppressed images about 15 times a second, suggesting timing matters for conscious vision. The observation links conscious vision to response timing as well as brain location.
Key points
Switching rate: about 15 times a second.
Suggests conscious vision may depend as much on timing as on brain location.
Sources
- Original post
- medicalxpress.com - Linked in the post
Single-nucleus atlas of 189 early-onset colorectal tumors released
Single-nucleus atlas of 189 tumors reveals age-associated differences in early-onset colorectal cancer. The study is published in Nature Medicine and includes a resource for further research.
Key points
Atlas: 189 tumors analyzed with single-nucleus profiling
Finding: age-associated differences in cell composition and expression in younger patients
Sources
- Original post
- nature.com - Linked in the post
Schmidt Center and ETH show adhesome genes clustered in nucleus
Schmidt Center and ETH report active adhesome genes and their regulators are spatially clustered in the nucleus. The finding suggests an association between chromatin organization and gene expression.
Key points
Active adhesome genes and their regulators are spatially clustered in the nucleus.
The clustering suggests a link between chromatin organization and gene expression.
Sources
- Original post
- journals.plos.org - Linked in the post
Selection tool picks diverse panel with high affinity
Selection tool enables picking a small, diverse panel with high predicted affinity, delivering the same discovery result from a fraction of the assays. It addresses redundancy in antibody campaign NGS sequences.
Key points
Antibody campaigns can return thousands of NGS sequences, many are redundant.
New Selection tool picks a small, diverse panel with high predicted affinity, giving the same discovery result from a fraction of the assays.
