Genmab announced that Petosentamab, a bispecific anti EGFRxLGR5 plus pembrolizumab, met both primary endpoints in R/M PDL1+ HNSCC. The trial reported overall survival hazard ratio 0.50 with 95% CI 0.37-0.67 (p<0.0001) and overall response rate 3.17 with 95% CI 2.06-4.89 (p<0.0001).
Key points
OS: HR 0.50 (95% CI, 0.37, 0.67); p<0.0001
ORR: 3.17 (95% CI, 2.06, 4.89); p<0.0001
Sources
Neuron block removes DBS memory gains in Rett mice
Neuron block removes DBS memory gains in Rett mice, showing newborn cells are essential. Blocking new neuron production eliminated deep brain stimulation’s memory benefits in Rett syndrome mice.
Key points
Blocking new neuron production eliminated deep brain stimulation’s memory benefits in Rett syndrome mice.
Newborn cells were essential to the gains.
Sources
- Original post
- medicalxpress.com - Linked in the post
CheckMate 8HW final overall survival results
CheckMate 8HW reported final overall survival (OS) data. NIVO combined with IPI significantly improved OS versus NIVO alone across all treatment lines. In first-line therapy, a clinically relevant trend toward improved OS was observed but did not reach statistical significance.
Key points
OS: NIVO plus IPI significantly improved overall survival versus NIVO across all lines
1L: trend toward improved OS observed, not statistically significant
Sources
- Original post
- doi.org - Linked in the post
UpToDate Expert AI demo at SGIM New England Regional Meeting Yale November 7
UpToDate Expert AI will be demonstrated live at the 2026 Society of General Internal Medicine New England Regional Meeting at Yale University on November 7. The demo highlights trusted evidence combined with generative AI for internal medicine teams.
Key points
Event: 2026 Society of General Internal Medicine New England Regional Meeting at Yale University, New Haven, CT, November 7.
Booth: UpToDate booth will show a live demo of UpToDate Expert AI.
Sources
Nextnet - new website for AI Ontology Infrastructure
Nextnet introduced a new website that highlights its AI Ontology Infrastructure for high-stakes operations. The site says structured knowledge and deterministic foundations aim to make AI more reliable, traceable and grounded.
Key points
New website announced for Nextnet.
AI Ontology Infrastructure placed at the center of the story.
Sources
TeselaGen and Tecnológico de Monterrey multi-year deal
TeselaGen and Tecnológico de Monterrey announced a multi-year collaboration to provide AI-powered tools for biological experiment design. The partnership gives TEC researchers access to TeselaGen's AI platform for designing constructs, managing workflows, and applying AI insights.
Key points
Multi-year collaboration agreement between TeselaGen and Tecnológico de Monterrey
TEC researchers will use TeselaGen's AI-powered platform for design, workflow management, and AI-assisted insights
Sources
Athelas Air note scoring with 95% first-pass rate announced
Athelas Air provides a plain-English answer to a PT’s question, offers next-month visit booking, and scores the note for compliance before signing. Lattimore scores every note before signing and reports a first-pass rate on claims over 95%. The demo will be shown at Booth 307 on November 12.
Key points
Air scores the note for compliance and highlights needed attention before signing.
Lattimore first-pass rate on claims is over 95%.
Sources
- Original post
- Walk the Clinic of the Future at PPS 2026 - Linked page