Drishtant Ghosh (Drix10)
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🤖 GeroScience Review - Intervertebral Disc Degeneration

⚡Direct Technical Summary

A new review by Victor Chen et al. provides a comprehensive overview of intervertebral disc degeneration and structural failure of the aging spine. This review brings together evid

🤖 GeroScience Review - Intervertebral Disc Degeneration

A new review by Victor Chen et al. provides a comprehensive overview of intervertebral disc degeneration and structural failure of the aging spine. This review brings together evidence on the cellular and molecular pathways underlying disc degeneration, which is a major contributor to age-related spinal disorders.

Key Points:

  • Cellular and Molecular Pathways: The review highlights the complex interplay between cellular and molecular mechanisms that contribute to disc degeneration, including inflammation, oxidative stress, and cellular senescence.

  • Structural Failure: The review discusses the structural changes that occur in the aging spine, including disc height loss, facet joint degeneration, and vertebral body osteoporosis.

  • Implications for Spinal Disorders: The review emphasizes the importance of understanding the underlying mechanisms of disc degeneration in order to develop effective treatments for age-related spinal disorders.

🔗 Resources:

🚀 International Longevity Month

For A4LI, this month is a chance to celebrate the scientists, researchers, entrepreneurs, advocates, policymakers, and everyone else working to make longer, healthier lives a reality. Longevity science is moving quickly, and there is a growing recognition of the importance of this field.

Key Points:

  • Celebrating Longevity Science: International Longevity Month is a chance to celebrate the progress being made in longevity science and to recognize the contributions of those working in this field.

  • Growing Recognition: There is a growing recognition of the importance of longevity science, with many organizations and governments investing in research and development in this area.

  • Future Directions: The future of longevity science holds much promise, with potential breakthroughs in areas such as senolytics, stem cell therapy, and artificial intelligence.

🔗 Resources:

🤖 Thermo AI Research

We’re using RL to post-train models for Thermo AI research, accelerating algorithmic discovery for our new species of computer. The first sparks of Thermo RSI, in collaboration with @PrimeIntellect.

Key Points:

  • Post-training Models: We are using reinforcement learning to post-train models for Thermo AI research, which is accelerating algorithmic discovery.

  • Thermo RSI: The first sparks of Thermo RSI, a new species of computer, are being developed in collaboration with @PrimeIntellect.

  • Accelerating Discovery: The use of post-training models is accelerating algorithmic discovery, which is a key aspect of Thermo AI research.

🔗 Resources:

🚀 Prime Intellect

Using Prime Intellect, Extropic post-trained Qwen3.6-35B-A3B for thermodynamic ML research, nearly tripling its eval results on held-out tasks in ~100 GRPO steps. They built a custom RL environment with verifiers and trained on Hosted Training, Prime Sandboxes, and Prime.

Key Points:

  • Post-training Qwen3.6-35B-A3B: Extropic used Prime Intellect to post-train Qwen3.6-35B-A3B, which nearly tripled its eval results on held-out tasks.

  • Custom RL Environment: A custom RL environment was built with verifiers and trained on Hosted Training, Prime Sandboxes, and Prime.

  • Thermodynamic ML Research: The post-training was used for thermodynamic ML research, which is a key area of study in the field of machine learning.

🔗 Resources:

🚀 Moonshots

@astroteller told me the formula for creating Moonshots is insanely simple during Moonshots Live: 1. Find hyper-energetic people who are delusionally optimistic 2. Find someone willing to pour money on them. The catch? Terrible ROI.

Key Points:

  • Moonshots Formula: The formula for creating Moonshots is to find hyper-energetic people who are delusionally optimistic and someone willing to pour money on them.

  • Terrible ROI: The catch is that the ROI is terrible, which means that the investment may not be worth it.

  • Moonshots Live: The formula was discussed during Moonshots Live, which is a platform for discussing and learning about Moonshots.

🔗 Resources:

🚀 Lifespan Research Institute

Today is International Longevity Day. At Lifespan Research Institute, we’re working toward a future where growing older doesn’t have to mean an ever-increasing burden of disease. That future won’t come from a single discovery. It takes an ecosystem.

Key Points:

  • International Longevity Day: Today is International Longevity Day, which is a celebration of the progress being made in the field of longevity.

  • Lifespan Research Institute: The Lifespan Research Institute is working towards a future where growing older doesn’t have to mean an ever-increasing burden of disease.

  • Ecosystem: The future won’t come from a single discovery, but rather from an ecosystem of research and development.

🔗 Resources:

🚀 Quantum-Computing Self-Consistent Kohn-Sham DFT

Quantum-Computing Self-Consistent Kohn-Sham DFT: Plane-Wave-Orthonormalized Orbitals with a Dual-Basis Quantum Eigensolver Lazaro Calderin https://arxiv.org/abs/2609.33934 ↗

Key Points:

  • Quantum-Computing Self-Consistent Kohn-Sham DFT: This is a quantum computing method for solving the Kohn-Sham DFT problem.

  • Plane-Wave-Orthonormalized Orbitals: The method uses plane-wave orthonormalized orbitals to solve the problem.

  • Dual-Basis Quantum Eigensolver: The method uses a dual-basis quantum eigensolver to solve the problem.

🔗 Resources:

🚀 Omaveloxolone

Omaveloxolone, an approved Friedreich’s ataxia drug, degraded STING in aged male mice and reduced inflammatory phenotypes. NRF2 activation may also contribute. A striking repurposing lead for inflammaging, but not yet human aging evidence.

Key Points:

  • Omaveloxolone: Omaveloxolone is a drug that has been approved for the treatment of Friedreich’s ataxia.

  • Degradation of STING: The drug degraded STING in aged male mice, which reduced inflammatory phenotypes.

  • NRF2 Activation: NRF2 activation may also contribute to the effects of the drug.

🔗 Resources:

🚀 Nonlinear Engineering of Hong-Ou-Mandel Interference

Nonlinear engineering of Hong-Ou-Mandel interference with structured light Simon Darveau, Bienvenu Ndagano https://arxiv.org/abs/2609.33862 ↗

Key Points:

  • Nonlinear Engineering of Hong-Ou-Mandel Interference: This is a method for nonlinearly engineering Hong-Ou-Mandel interference with structured light.

  • Structured Light: The method uses structured light to achieve the nonlinear engineering.

  • Hong-Ou-Mandel Interference: The method is used to study Hong-Ou-Mandel interference.

🔗 Resources:

🚀 Buck Institute

Changes at the NIH have resulted in the loss of $11 million in grant funding that was expected to come to Buck. We need your help to keep vital research moving forward. Stand with our scientists. Stand with Buck Science.

Key Points:

  • Loss of Grant Funding: The NIH has lost $11 million in grant funding that was expected to come to Buck.

  • Impact on Research: The loss of funding will impact the research being conducted at Buck.

  • Support for Scientists: The Buck Institute is calling on supporters to help keep vital research moving forward.

🔗 Resources:

📂Source / Implementation:Quantum Computing / resources-231.md
GitHub Repository↗

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Drishtant Ghosh (Drix10)
Drishtant Ghosh (Drix10)•Author & Engineer

Technical founder and engineer working across AI systems, developer infrastructure, and cybersecurity.

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GitHub: Quantum Computing/resources-231.md ↗https://blogs.drix10.com/articles/quantum-computing/geroscience-review-intervertebral-disc-degeneration-231