Prime editing was used to edit DNA directly in a person’s body for the first time, treating Wilson’s disease by correcting a liver-cell mutation. The treatment is part of Prime Medicine’s clinical trial and results are expected next year.
Key points
First known in-vivo use of prime editing on a human participant.
Targeted ATP7B gene mutation to erase excess-copper buildup in liver cells.
Sources
Insular cortex mapping reveals pain and visceral sensation regions
Scientists mapped the human insula in detail, showing distinct zones for pain, heat, tingling and visceral sensations like nausea. The study used electrical stimulation in 87 patients with implanted electrodes.
Key points
87 participants with clinically implanted brain electrodes were stimulated to map insular functions.
Rear insula stimulation produced pain, heat, tingling and numbness; middle insula stimulation produced nausea, pressure and fullness in the chest.