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Neoantigen vaccine + PD-1 blockade phase 1 trial

, 4 items in Neuroscience and AI, 2 min read

In this digest (4 items)

Neoantigen vaccine + PD-1 blockade phase 1 trial was feasible and generated tumor-specific immune responses in many patients. The trial involved high-grade serous ovarian cancer.

Key points

  • Feasibility: treatment was feasible.

  • Immune response: led to tumor-specific immune responses in many patients.

Sources

Voyager 1 reaches one light-day from Earth

Voyager 1 has been breaking its own distance records for years. It is now one light-day from Earth.

Key points

  • Distance record: breaking its own distance records for years

  • Current distance: one light-day from Earth

Sources

Johnson & Johnson–Bristol Myers Squibb alliance stroke update

Johnson & Johnson–Bristol Myers Squibb alliance update on stroke prevention, FXI(a) inhibition, and emerging anticoagulant research is now available on demand. Industry Therapeutic Updates are accessible through the AAN Online Learning Center.

Key points

  • Alliance update covers stroke prevention, FXI(a) inhibition, emerging anticoagulant research.

  • Industry Therapeutic Updates are now on demand via the AAN Online Learning Center.

Sources

Updates in MSA – CSF assay distinguishes MSA with type 2 fluorescence

Updates in MSA reports a CSF seeding assay that uses thioflavin T fluorescence to differentiate MSA from controls, showing a type 2 response pattern. The assay reports high specificity and sensitivity. Prevalence estimates cite MSA at 2–5 per 100,000 and Parkinson’s disease at 130–170 per 100,000.

Key points

  • CSF assay produces a type 2 fluorescence response linked to MSA.

  • Reported prevalence: MSA 2–5/100,000, Parkinson’s disease 130–170/100,000.

Sources