lenacapavir generic injectable approved by FDA; protects from HIV for 6 months and will be sold for $40 per person per year.
Key points
FDA approval of generic injectable lenacapavir
Pricing pledged at $40 per person per year
Protection duration of 6 months per dose
Manufacturer Dr. Reddy’s Laboratories will market the drug
Sources
- Original post
- scim.ag - Linked in the post
Martian meteorite - formed 4.1 billion years ago
Martian meteorite found in the Sahara Desert formed at least 4.1 billion years ago, providing a sample of Mars’ early crust. New study published in Science reports this result.
Key points
Location: Sahara Desert
Age: at least 4.1 billion years, sample of early Martian crust
Sources
- Original post
- scim.ag - Linked in the post
Azetukalner reduces focal seizure frequency in adults
Azetukalner reduced seizure frequency versus placebo in adults with focal epilepsy who had ongoing focal seizures despite 1-3 antiseizure meds, showing rapid and durable benefit over a 12-week double-blind period. The result comes from a trial of patients with continued focal seizures.
Key points
Reduced seizure frequency vs placebo in adults with focal epilepsy.
Benefit was rapid and durable during the 12-week double-blind period.
Sources
- Original post
- ja.ma - Linked in the post
Castration extends male mouse lifespan by over 30%
Castration extends male mouse lifespan by over 30% when performed on older mice. Researchers report neutering older male mice lengthens their lives by more than 30%, upending prior assumptions about timing.
Key points
Removing the testicles extends male life span across many mammalian species, including humans.
Neutering older male mice lengthens their lives by more than 30%.
Sources
- Original post
- scim.ag - Linked in the post
hair analysis yields earliest direct evidence of psychoactive cannabis
hair analysis of a 2800-year-old tomb provides the earliest direct evidence of psychoactive cannabis use. Findings appear in Science and discuss the plant’s role in ancient societies.
Key points
2800-year-old tomb hair analysis
earliest direct evidence of psychoactive cannabis use
Sources
- Original post
- scim.ag - Linked in the post
RIMKLA-IgG identified as biomarker for paraneoplastic syndrome
RIMKLA-IgG identified as a new biomarker of paraneoplastic neurological syndrome with cerebellar ataxia, hindbrain encephalitis, inflammatory cerebrospinal fluid, and frequent Small Cell Lung Cancer. The syndrome includes cerebellar ataxia and hindbrain encephalitis.
Key points
RIMKLA-IgG identified as new biomarker of paraneoplastic neurological syndrome
Associated with cerebellar ataxia, hindbrain encephalitis, inflammatory cerebrospinal fluid, and frequent Small Cell Lung Cancer
Sources
- Original post
- ja.ma - Linked in the post
CD19 ChimericAntigenReceptor T-cell therapy single dose improves mobility
CD19 ChimericAntigenReceptor T-cell therapy for Stiff Person Syndrome was given as a single dose and showed clinically meaningful mobility improvement. The treatment also showed changes supportive of immune reset and had a manageable safety profile.
Key points
Single dose associated with clinically meaningful mobility improvement
Changes supportive of immune reset observed
Manageable safety profile reported
Sources
- Original post
- ja.ma - Linked in the post
ScienceMagazine GLP-1 and Beyond special issue review
ScienceMagazine GLP-1 and Beyond special issue includes a Review on obesity pharmacotherapies and cognition. The review explores potential effects on brain health and outlines remaining questions.
Key points
Special issue of ScienceMagazine on “GLP-1 and Beyond” is out this week.
Contributed a Review on obesity pharmacotherapies and cognition.
Sources
- Original post
- science.org - Linked in the post