Accelerated loss of naive CD8 T cells in male mice leads to lymph node contraction and limited cancer antigen recognition. Restoring thymic output improves responses to immunotherapy in middle‑aged male mice.
Key points
Accelerated loss of naive CD8 T cells causes lymph node contraction.
Restoring thymic output improves immunotherapy responses in middle‑aged male mice.
Sources
- Original post
- Linked resource - Linked in the post
- Linked resource - Linked in the post
STING drives NF-κB signaling via IKK recruitment
STING drives NF-κB signaling. It does so by recruiting the IKK complex. The recruitment is M1-linked ubiquitin-dependent and IRF3-independent.
Key points
Signaling: STING drives NF-κB signaling.
Recruitment: STING recruits the IKK complex in an M1-linked ubiquitin-dependent but IRF3-independent manner.
Sources
- Original post
- Linked resource - Linked in the post
Flock cuts ~270 jobs amid privacy backlash
Flock Safety announced it will let go of about 270 employees, roughly 18% of its workforce. The cuts follow a voluntary buyout program and come as the company faces regulatory and public scrutiny over its AI‑powered surveillance cameras. Flock has about 1,500 staff and operates around 120,000 cameras across 49 states. The company has raised over $950 million, including a $275 million round in March that valued it at $7.5 billion.
Key points
Job cuts: about 270 employees will leave at the end of the month, representing roughly 18% of Flock’s 1,500‑person staff.
Deployment: Flock’s network includes about 120,000 AI‑powered cameras in 49 states, serving over 4,800 law‑enforcement agencies and nearly 1,000 businesses.