SigVie-002 phase III trial shows no OS benefit, OS 11.9 vs 11.5 months (HR 0.93, p=0.226). No significant PFS improvement and exploratory analysis showed no clear efficacy trend by integrin β6 expression.
Key points
OS: 11.9 vs 11.5 months (HR 0.93; p=0.226)
PFS: 4.7 vs 4.2 months (HR 0.84); no clear efficacy trend by IB6 expression
Sources
Electrical Stimulation modulates immune cells – microglia track active neurons
Electrical Stimulation modulates immune cells reports that microglia extend arms toward neurons activated by stimulation, not just the electrode. Microglia become reactive within minutes of implantation and alter stimulation-driven network activity.
Key points
Microglia nearby aimed their arms at the active cells, not only at the electrode.
Within minutes of the electrode insertion, microglia switch to a reactive state and reach for the implant.
Sources
- Original post
- Electrical Stimulation modulates immune cells - Linked page
EGFR OptiTroplung04 trial shows 7-month benefit
EGFR OptiTroplung04 trial shows a 7-month OS benefit with primary endpoint met. No Osi in either arm. Sac arm had fewer subsequent therapies but more toxicity.
Key points
OS primary endpoint achieved
No Osi in either arm
Sac arm had less subsequent therapies and more toxicity
Sources
HuggingFace Hub OpenUSD support, 2500+ SimReady assets
HuggingFace Hub now supports OpenUSD format and hosts over 2,500 SimReady assets from NVIDIA Omniverse. The library can be searched in plain English.
Key points
OpenUSD support added on the HuggingFace Hub
2,500+ SimReady assets uploaded by NVIDIA Omniverse, including forklifts, robot arms, engines, hospital equipment
Sources
Vizuara AI Pods – Build a World Model from Scratch
Vizuara AI Pods released a “Build a World Model from Scratch” course that covers MiniPong, RSSMs, IRIS and neural network outcome prediction. The material includes a complete pipeline with an encoder, GRU memory and prediction head trained on MiniPong.
Key points
Course explores MiniPong, RSSMs, IRIS and neural network prediction of outcomes.
Includes building an encoder, GRU memory and prediction head that learn MiniPong.
Sources
- Original post
- Vizuara AI Pods - Linked page
PricePush 2.0 move prices before localizing
PricePush 2.0 adds a feature to raise or lower every price by a percentage before localizing. The percentage move can be the same on both stores or different on each. It applies only to that run and never stacks.
Key points
Feature: move all prices by a percentage before localizing.
Scope: applies to that run only, never stacks.
